Peptide ligands for binding to EphA2

US11814447B2 · kind B2 · utility

Assignee

• BicycleRD Limited · GB

Inventors

• Daniel Paul Teufel · Cambridge, GB
• Gemma MUDD · Cambridge, GB
• Silvia Pavan · Cambridge, GB

Key dates

• Filing date: Jun 18, 2019
• Grant date: Nov 14, 2023
• Expiry date: Jun 18, 2039

Classification

• Technology area (CPC G): Physics
• CPC primary: G01N2333/9121
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A peptide ligand specific for EphA2 comprising a polypeptide comprising three residues selected from cysteine, L-2,3-diaminopropionic acid (Dap), N-beta-alkyl-L-2,3-diaminopropionic acid (N-AlkDap) and N-beta-haloalkyl-L-2,3-diaminopropionic acid (N-HAlkDap), with the proviso that at least one of said three residues is selected from Dap, N-AlkDap or N-HAlkDap, the said three residues being separated by at least two loop sequences, and a molecular scaffold, the peptide being linked to the scaffold by covalent alkylamino linkages with the Dap or N-AlkDap or N-HAlkDap residues of the polypeptide and by thioether linkages with the cysteine residues of the polypeptide when the said three residues include cysteine, such that two polypeptide loops are formed on the molecular scaffold.