Patent · US Active

Poly(amine-co-ester) polymers and polyplexes with modified end groups and methods of use thereof

US11814464B2 · kind B2 · utility

1Cited by
18References
27Claims
0Family size

Assignee

Inventors

Key dates

Filing dateApr 29, 2020
Grant dateNov 14, 2023
Priority date—
Expiry dateJan 9, 2042

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N15/88
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Poly(amine-co-ester) polymers, methods of forming active agent-load polyplexes and particles therefrom, and methods of using them for delivery of nucleic acid agents with optimal uptake have been developed. Examples demonstrate critical molecular weights in combination with exposed carboxylic and/or hydroxyl groups, and methods of making. Typically, the compositions are less toxic, more efficient at drug delivery, or a combination thereof compared to a control other transfection reagents. In some embodiments, the compositions are suitable for in vivo delivery, and can be administered systemically to a subject to treat a disease or condition.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.