Line scanning mechanical streak systems and methods for phosphorescence lifetime imaging
US11815456B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Aug 25, 2021 |
| Grant date | Nov 14, 2023 |
| Priority date | — |
| Expiry date | Jan 18, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2201/1053
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Systems and methods for analyzing samples, such as tissue samples, and measuring the emissions when these samples are exposed to light are disclosed. Embodiments include illuminating multiple target locations on a sample with laser light, which may first be manipulated by a scanner, and receiving decaying emissions from the target location. At least some embodiments include the emissions traveling backwards along a substantial portion of the laser light pathway and being received by a detector. Additional embodiments include converting the received emissions into streak lines of position versus time, converting the streak lines to plots of signal strength versus time, and curve fitting the plots to determine representative decay times. In some embodiments, the decay times are presented as plots of position on the surface of the sample versus emission strength, which may be color coded. Some embodiment dwell on each target location for multiple scans of the laser.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.