Methods and compositions related to toxicity associated with cell therapy

US11815514B2 · kind B2 · utility

Assignees

• Juno Therapeutics, Inc. · US
• Fred Hutchinson Cancer Research Center · US

Inventors

• He Li · Shanghai, CN
• Mark J. GILBERT · Seattle, US
• David MALONEY · Point of Rocks, US
• Stanley R. Riddell · Bothell, US
• Cameron J. Turtle · Seattle, US

Key dates

• Filing date: Dec 2, 2016
• Grant date: Nov 14, 2023
• Expiry date: Nov 15, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/03
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided are methods, kits and compositions related to toxicity associated with administration of cell therapy for the treatment of diseases or conditions, e.g., cancer, including methods for use in predicting and treating a toxicity. In some embodiments, the toxicity is a neurotoxicity or cytokine release syndrome (CRS), such as a severe neurotoxicity or a severe CRS. The methods generally involve detecting a parameter of a biomarker or individually a parameter of each biomarker in a panel of biomarkers, such as a concentration, amount or activity, and comparing the detected parameter to a reference value for the parameter to determine if the subject is at risk for developing the toxicity, such as neurotoxicity or CRS or severe neurotoxicity or severe CRS. In some embodiments, the methods further involve administering an agent or therapy for treating, ameliorating, preventing, delaying and/or attenuating the development of the toxicity, such as neurotoxicity or CRS, such as severe neurotoxicity or severe CRS.