Patent · US Active

Method for preparing 2-ethyl-4-fluoro-1-nitrobenzene

US11820724B2 · kind B2 · utility

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20Claims

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Assignee

ACCELA CHEMBIO CO., LTD. · CN

Inventors

Yang Liu · Shanghai, CN
Duoqing Xue · Shanghai, CN
Yong Wu · Shanghai, CN
Lihuang Chen · Shanghai, CN
Lianhua Zhai · Shanghai, CN

Key dates

Filing date	Sep 10, 2020
Grant date	Nov 21, 2023
Priority date	—
Expiry date	Nov 10, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07C201/12
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

The present disclosure provides a method for preparing 2-ethyl-4-fluoro-1-nitrobenzene, including: (1) nitrifying 3-fluoroacetophenone with a nitration reagent, to obtain 1-(5-fluoro-2-nitrophenyl)ethanone; (2) reducing 1-(5-fluoro-2-nitrophenyl)ethanone with a reducing agent, to obtain 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene; (3) iodinating 4-fluoro-2-(1-hydroxyethyl)-1-nitrobenzene, to obtain 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene; and (4) reducing 4-fluoro-2-(1-iodoethyl)-1-nitrobenzene with a reducing agent, to obtain 2-ethyl-4-fluoro-1-nitrobenzene.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.