Purification method and device for continuous distillation and separation of ibuprofen intermediate raw material
US11820743B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Aug 5, 2022 |
| Grant date | Nov 21, 2023 |
| Priority date | — |
| Expiry date | Aug 5, 2042 |
Classification
- Technology area (CPC Y)Emerging Cross-Sectional Technologies
- CPC primaryY02P20/10
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
The present disclosure belongs to the technical field of chemical separation and purification, and in particular relates to a purification method and device for continuous distillation and separation of an ibuprofen intermediate raw material. The purification method comprises the following steps: carrying out a primary distillation on synthetic liquid to obtain a primary material and recovered 4-methyl-1-pentene, then carrying out a second-stage distillation on the primary material to obtain a second-stage material and a recovered crude toluene product; and carrying out a third-stage distillation on the second-stage material to obtain isobutyl benzene and a recovered crude n-butylbenzene product. Embodiment results show that the purification method provided by the present disclosure is high in product recovery rate and high in product purity, the purity of isobutyl benzene is up to 99.99 wt %, the recovery rate is up to 99.9 wt %, the impurity content is not higher than 50 ppm.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.