Monoacylglycerol lipase modulators

US11820766B2 · kind B2 · utility

Assignee

• Janssen Pharmaceuticals, Inc. · BE

Inventors

• Michael K. Ameriks · San Diego, US
• Gang Chen · Sammamish, US
• Chaofeng Huang · San Diego, US
• Brian Ngo Laforteza · San Diego, US
• Suchitra Ravula · San Diego, US
• Emma Helen Southgate · Mountain View, US
• Wei Zhang · San Diego, US

Key dates

• Filing date: Dec 23, 2020
• Grant date: Nov 21, 2023
• Expiry date: Dec 23, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Fused compounds of Formula (I) and Formula (II), pharmaceutical compositions containing them, methods of making them, and methods of using them including methods for treating disease states, disorders, and conditions associated with MGL modulation, such as those associated with pain, psychiatric disorders, neurological disorders (including, but not limited to major depressive disorder, treatment resistant depression, anxious depression, bipolar disorder), cancers and eye conditions. Wherein R1, R2, R2a, R3, R3a, R4, and R4a are defined herein.