Patent · US Active

Ligand and use thereof

US11820802B2 · kind B2 · utility

0Cited by

0References

22Claims

0Family size

Assignee

Cytiva BioProcess R&D AB · SE

Inventors

Sophia Hober · Stockholm, SE
Sara Kanje · Stockholm, SE
Johan Nilvebrant · Täby, SE

Key dates

Filing date	Sep 5, 2017
Grant date	Nov 21, 2023
Priority date	—
Expiry date	Jan 29, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/705
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

The present invention is within the field of protein engineering and purification. The invention relates to a target-binding polypeptide mutant of an IgG binding polypeptide, such as Protein A, Protein G, Protein L or Protein M, comprising a metal binding motif. More closely the invention relates to an Fc binding ligand comprising an engineered protein based on the Protein A derived Z domain, to which a calcium binding EF-loop has been introduced.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.