Multispecific antibodies facilitating selective light chain pairing

US11820809B2 · kind B2 · utility

Assignee

• Sanofi · FR

Inventors

• Ercole Rao · Frankfurt am Main, DE
• Christian Beil · Frankfurt am Main, DE
• Christian Lange · Frankfurt am Main, DE
• Katja Kroll · Frankfurt, DE
• Wulf-Dirk Leuschner · Frankfurt am Main, DE
• Ingo Focken · Hofheim, DE
• Thomas LANGER · Frankfurt am Main, DE
• Nadja Spindler · Frankfurt am Main, DE

Key dates

• Filing date: Aug 25, 2017
• Grant date: Nov 21, 2023
• Expiry date: Aug 25, 2037

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/92
• WIPO field: Biotechnology
• WIPO sector: Chemistry

Abstract

Provided herein are multispecific antibodies, e.g. bispecific antibodies, which are modified such that the desired chain pairing takes place and/or can be selected for. Specifically, this is achieved by using different dimerization domains for light chain pairing. Also disclosed herein are nucleic acids encoding for these antibodies, expression vectors comprising these nucleic acids, cells expressing them, and further to pharmaceutical compositions comprising the antibodies, as well as methods of isolating the antibodies.