Patent · US Active

Methods for producing fabs and IgG bispecific antibodies

US11820828B2 · kind B2 · utility

0Cited by

0References

34Claims

0Family size

Assignees

ELI LILLY AND COMPANY · US
The University of North Carolina at Chapel Hill · US

Inventors

Stephen Demarest · San Diego, US
Karen Jean Froning · Escondido, US
Brian Arthur Kuhlman · Chapel Hill, US
Andrew Philip Leaver-Fay · Carrboro, US

Key dates

Filing date	Dec 14, 2017
Grant date	Nov 21, 2023
Priority date	—
Expiry date	Oct 30, 2038

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC07K2319/00
WIPO fieldBiotechnology
WIPO sectorChemistry

Abstract

Methods for producing Fabs and IgG bi-specific antibodies comprising expressing nucleic acids encoding designed residues in the CH1/CL interface are provided. Also provided are Fabs and IgG bi-specific antibodies produced according to the provided methods as well as nucleic acids, vectors and host cells encoding the same.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.