Patent · US Active

Compositions and methods for improving nanopore sequencing

US11821033B2 · kind B2 · utility

0Cited by
6References
15Claims
0Family size

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Inventors

Key dates

Filing dateDec 3, 2020
Grant dateNov 21, 2023
Priority date—
Expiry dateDec 10, 2041

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12Q1/6869
  • WIPO fieldBiotechnology
  • WIPO sectorChemistry

Abstract

The present disclosure provides methods and reagents for improving nanopore-based analyses of polymers. Specifically, the disclosure provides a method of analyzing a polymer that includes a polymer analyte that contains an end domain that has at least one charged moiety. The disclosure also provides a method of increasing the interaction rate between a polymer analyte and a nanopore, wherein the polymer analyte contains an end domain that has at least one charged moiety. The disclosure also provide compositions for use with the described methods, including adapter compositions that contain charged moieties, such as phosphate or sulfate groups, and that are configured to being linked to an polymer analyte domain.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.