Method for preparing a large animal model with peritoneal carcinomatosis
US11825818B2 · kind B2 · utility
Inventors
Key dates
| Filing date | Apr 11, 2020 |
| Grant date | Nov 28, 2023 |
| Priority date | — |
| Expiry date | Jan 8, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0331
- WIPO fieldOther special machines
- WIPO sectorMechanical engineering
Abstract
The present invention relates to a method for preparing a large animal model, with peritoneal carcinomatosis, which is an abdominal cavity metastasis of tumor commonly found in advanced or recurrent solid cancer, is induced using a large animal, and the method for preparing a large animal model with peritoneal carcinomatosis comprises injecting a cancer cell line into the abdominal cavity of a piglet in which the immune function is not completed. The method for preparing a large animal model with peritoneal carcinomatosis, when a human-derived immortalized cell line is inoculated into a pig, can overcome xenograft rejection and induce peritoneal carcinomatosis, can use animals with sufficient supply and demand, and can expect the spread of peritoneal carcinomatosis through breeding.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.