Poly-glutamine androgen receptor knock-in mouse models, reagents and methods
US11825820B2 · kind B2 · utility
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17Claims
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Key dates
| Filing date | Mar 29, 2018 |
| Grant date | Nov 28, 2023 |
| Priority date | — |
| Expiry date | Nov 16, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA01K2267/0393
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A knock-in non-human mammal comprising a recombinant androgen receptor (AR) cassette containing an exogenous human polyglutamine (polyQ) tract encoding sequence in exon 1, wherein the human polyQ tract encoding sequence is stably integrated into the genome of the animal. Also provided are recombinant cells, fertilized eggs and tissues. The resulting animal displays a wide range of phenotypes, best characterized as Metabolic Syndrome and can be used in screening and other assays.
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