Patent · US Active

Method for measuring water exchange across the blood-brain barrier using MRI

US11826134B2 · kind B2 · utility

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Key dates

Filing dateJun 11, 2020
Grant dateNov 28, 2023
Priority date—
Expiry dateAug 29, 2041

Classification

  • Technology area (CPC G)Physics
  • CPC primaryG01R33/56509
  • WIPO fieldMeasurement
  • WIPO sectorInstruments

Abstract

A method for measuring water exchange across the blood-brain barrier includes acquiring diffusion weighted (DW) arterial spin labeling (ASL) magnetic resonance imaging (MRI) signals. The method further includes determining optimal parameters to separate labeled water in capillary and brain tissue compartments. The method further includes estimating water exchange rate across the blood-brain barrier based on the DW ASL MRI signals and the optimal parameters, using a total generalized variation (TGV) regularized single-pass approximation (SPA) modeling algorithm.

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