Full continuous-flow preparation method of L-carnitine

US11827581B2 · kind B2 · utility

Assignee

• FUDAN UNIVERSITY · CN

Inventors

• Fener CHEN · Shanghai, CN
• Minjie LIU · Shanghai, CN
• Meifen JIANG · Shanghai, CN
• Dang CHENG · Shanghai, CN
• Chao YU · Shanghai, CN
• Huashan HUANG · Shanghai, CN

Key dates

• Filing date: May 10, 2022
• Grant date: Nov 28, 2023
• Expiry date: May 10, 2042

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B01J2219/00889
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

A full continuous-flow preparation method of L-carnitine, including: mixing chlorine gas and a diketene solution via a first micromixer followed by transportation to a first microchannel reactor for continuous chlorination and esterification reaction to obtain 4-chloroacetoacetate; feeding the 4-chloroacetoacetate and a reductase to a second micromixer and a second microchannel reactor in sequence for continuous catalytic reaction to obtain (R)-4-chloro-3-hydroxybutyrate; simultaneously transporting the (R)-4-chloro-3-hydroxybutyrate and a trimethylamine solution to a third micromixer and a third microchannel reactor for continuous substitution and hydrolysis reaction; and subjecting the reaction mixture to desalination and concentration to obtain the L-carnitine.