Crystalline forms of trofinetide

US11827600B2 · kind B2 · utility

Assignee

• ACADIA Pharmaceuticals Inc. · US

Inventors

• Matthew Peterson · Hopkinton, US
• Marlon Carlos · Chula Vista, US
• Martin Bernard Catherine Bousmanne · Woluwe-Saint-Lambert - Sint-Lambrechts-Woluwe, BE
• Cecilia Betti · Brussels, BE
• David Jonaitis · Lafayette, US
• Lisa M. McCracken · Lafayette, US
• Lisa Michelle Grove · Lafayette, US

Key dates

• Filing date: Jul 12, 2022
• Grant date: Nov 28, 2023
• Expiry date: Jul 12, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure provides crystalline forms of trofinetide and trofinetide hydrate, pharmaceutical compositions comprising crystalline forms of trofinetide and trofinetide hydrate, methods of making crystalline forms of trofinetide or trofinetide hydrate, and methods of treating a disease, condition, or disorder in a subject comprising administering a composition comprising crystalline forms of trofinetide or trofinetide hydrate to the subject.