Processes and intermediate for the large-scale preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate, and preparation of 2,4,6-trifluoro-n-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide acetate

US11827618B2 · kind B2 · utility

Inventors

• Aktham Aburub · Carmel, US
• David Coates · Bishop's Stortford, GB
• Scott Alan Frank · Indianapolis, US
• Mark Steven Kerr · Indianapolis, US
• Roger Ryan Rothhaar · Reelsville, US
• Radhe Krishan Vaid · West Lafayette, US

Key dates

• Filing date: Apr 14, 2023
• Grant date: Nov 28, 2023
• Expiry date: Apr 14, 2043

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The embodiments of present invention provide processes and an intermediate for the large-scale preparation of 2,4,6-trifluoro-N-[6-(1-methylpiperidine-4-carbonyl)-2-pyridyl]benzamide hemisuccinate, and formulations and product forms, such as tablets, made by these processes. Additionally, embodiments of the present invention provide tablets including 25 mg, 50 mg, 100 mg, or 200 mg free base equivalent of 2,4,6-trifluoro-N-[6-(1-methyl-piperidine-4-carbonyl)-pyridin-2-yl]-benzamide hemisuccinate.