Terminal sterilization filtration closed lyophilization in a container

US11833108B2 · kind B2 · utility

Assignees

• Baxter International Inc. · US
• Baxter Healthcare SA · CH

Inventors

• Mark Doty · Grayslake, US
• Christine L. Rebbeck · Lake Barrington, US
• Sydney J. Cope · Chicago, US
• William S. Hurst · Burlington, US
• Grant Anthony Bomgaars · Kildeer, US
• Yuanpang Samuel Ding · Libertyville, US
• Thomas E. Dudar · Palatine, US
• Ying-Cheng Lo · North Aurora, US
• Mark Edward Pasmore · Grayslake, US
• Michael Joseph Sadowski · Ringwood, US
• Anastasios Hristakos · Evanston, US
• Joseph V. Ranalletta · Guntersville, US
• Bernd Krause · Liederbach, DE

Key dates

• Filing date: Jul 12, 2018
• Grant date: Dec 5, 2023
• Expiry date: Apr 1, 2041

Classification

• Technology area (CPC F): Mechanical Engineering; Lighting; Heating
• CPC primary: F26B5/06
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

A sterile solution product bag for lyophilizing includes a bladder, a first stem having a first stem inlet end and a first stem outlet end. The first stem outlet end is fluidly connected to the bladder and the first stem inlet end is adapted to receive a liquid. A first filter is disposed in-line with the first stem and includes a first filter membrane, a first filter open end, and a first filter closed end. The first filter closed end is disposed between the first stem inlet end and the first stem outlet end and the first filter open end is disposed in proximity to the first stem inlet end. A second stem having a second stem inlet end fluidly connected to the bladder and a second stem outlet end adapted to receive a vapor. A second filter is disposed within the second stem and includes a filter membrane.