Bifidobacterium longum for treating obesity and weight management

US11833178B2 · kind B2 · utility

Assignees

• UNIVERSITY COLLEGE CORK—NATIONAL UNIVERSITY OF IRELAND, Cork · IE
• AGRICULTURE AND FOOD DEVELOPMENT AUTHORITY (TEAGASC) · IE

Inventors

• John Cryan · Cork, IE
• Ted DINAN · Cobh, IE
• Catherine Stanton · Cork, IE
• Harriet Schellekens · Cork, IE
• Cristina Clotet Torres · Mollerussa, ES
• Bernard Roy · Cork, IE

Key dates

• Filing date: Aug 27, 2018
• Grant date: Dec 5, 2023
• Expiry date: Aug 29, 2038

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12R2001/01
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

A strain of Bifidobacterium longum APC 1472 is described. The strain has weight lowering effects in-vivo, achieved through inducing satiety via decreased internalisation of the Ghrelin receptor, and therefore, decreased constitutive activity. Moreover, the strain also showed a trend towards decreased ghrelin receptor hypothalamic expression in HFD-fed mice when compared with vehicle control group. The strain also improves glucose tolerance and decreased insulin plasma levels in mice, indicating the strain in the prevention and/or treatment of Type II diabetes, especially in obese individuals.