Combinatory separation

US11833524B2 · kind B2 · utility

Assignee

• LAB-ON-A-BEAD AB · SE

Inventors

• Sven Oscarsson · Örbyhus, SE
• Per-Olof Eriksson · Umeå, SE
• Kristofer Eriksson · Hagfors, SE

Key dates

• Filing date: Jun 13, 2018
• Grant date: Dec 5, 2023
• Expiry date: Feb 19, 2039

Classification

• Technology area (CPC B): Performing Operations; Transporting
• CPC primary: B03C2201/26
• WIPO field: Measurement
• WIPO sector: Instruments

Abstract

There is disclosed a combinatory separation system comprising: a first compartment adapted to handle a mixture with magnetic beads having an affinity for molecules, comprising a magnet to attract the beads, a second compartment adapted to receive said magnetic beads transferred thereto with a flow of liquid, and said at least one second compartment is adapted to elute said at least one type of molecules to be separated from said magnetic beads, said at least one second compartment has an outlet comprising means for retaining said magnetic beads in the at least one second compartment. Advantages include that the process becomes simpler quicker and thereby less expensive, since the method is able to remove cells and particles, separate molecules and perform virus inactivation in fewer steps compared to the prior art. Further the method is able to provide a more concentrated end product.