Method for producing cardiomyocytes
US11834679B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 24, 2019 |
| Grant date | Dec 5, 2023 |
| Priority date | — |
| Expiry date | Nov 29, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/1307
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The present invention chiefly aims to provide a process for directly inducing cardiomyocytes from somatic cells without performing artificial gene transfer, a cardiomyocyte obtained thereby, and a composition comprising a combination of chemical compounds capable of using for the said process. The present invention can include a process for producing a cardiomyocyte by inducing differentiation directly from a somatic cell, the process comprising a step of culturing the somatic cell in the presence of a MEK inhibitor and a cAMP inducer, and a cardiomyocyte obtained thereby, and then a composition for producing a cardiomyocyte by inducing differentiation directly from a somatic cell, the composition comprising a MEK inhibitor and a cAMP inducer. The cardiomyocytes obtained according to the present invention are useful in regenerative medicine and the like.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.