Method of testing a gene therapy vector
US11834722B2 · kind B2 · utility
Assignee
Inventor
Key dates
| Filing date | Jul 9, 2018 |
| Grant date | Dec 5, 2023 |
| Priority date | — |
| Expiry date | Sep 15, 2039 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2750/14143
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A method of determining the safety and/or efficacy of a gene therapy vector prior to carrying out gene therapy on an individual includes infecting a culture of induced pluripotent stem cells obtained from the individual with a gene therapy vector. Ideally the cells are allowed to differentiate, and the infection is carried out at the start of culture and at least once during differentiation and/or after differentiation. Nucleic acids are extracted from the infected cells, and then analysed to measure and/or determine adverse effects of integration of nucleic acid from the vector and/or efficiency of expression of nucleic acid from the vector.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.