Synthesis method of cyclosporine derivatives
US11840582B2 · kind B2 · utility
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2References
17Claims
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Key dates
| Filing date | Jul 12, 2021 |
| Grant date | Dec 12, 2023 |
| Priority date | — |
| Expiry date | Feb 19, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/027
- WIPO fieldChemical engineering
- WIPO sectorChemistry
Abstract
The present disclosure relates to a method of synthesizing cyclosporine derivatives. The method includes: providing a precursor fluid of the cyclosporine derivative, an alkaline fluid and a ClCH2OCOCl solution; premixing the precursor fluid and the alkaline fluid to obtain a premixed solution; feeding the premixed solution into a first reaction chamber, reacting to prepare a first reaction liquid; feeding the first reaction liquid into a second reaction chamber, reacting the first reaction liquid with a CO2 fluid to prepare a second reaction liquid; and reacting the second reaction liquid with the ClCH2OCOCl solution.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.