Patent · US Active

Allele selective inhibition of mutant C9orf72 foci expression by duplex RNAs targeting the expanded hexanucleotide repeat

US11840690B2 · kind B2 · utility

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2References

37Claims

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Assignee

The Board of Regents of the University of Texas System · US

Inventors

David R. Corey · Dallas, US
Jiaxin Hu · Coppell, US

Key dates

Filing date	Nov 17, 2021
Grant date	Dec 12, 2023
Priority date	—
Expiry date	Nov 17, 2041

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N2310/3521
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided herein are compositions and methods for reducing expression of C9orf72 transcripts in cells containing expanded intronic GGGGCC regions, including those in subjects having or at risk of developing amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD).

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.