Patent · US Active

Nucleic acid biomarker and use thereof

US11840736B2 · kind B2 · utility

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0References

14Claims

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Assignees

Inventors

Matthias Schneider · Dossenheim, DE
Sabine BLUM · Munich, DE
Renee Jeanne MENDELL-HARARY · Skillman, US
Daniel J. Freeman · Newbury Park, US
Robert Allen BECKMAN · Blue Bell, US
Xiaoping Jin · Orange, US

Key dates

Filing date	Aug 21, 2019
Grant date	Dec 12, 2023
Priority date	—
Expiry date	Dec 1, 2040

Classification

Technology area (CPC G)Physics
CPC primaryG01N2333/4704
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

The present invention is directed to methods of identifying and treating a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and administering a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as high. The present invention is also directed to methods of identifying a human subject harboring a tumor or other disease comprising assessing HRG gene expression at an mRNA level in the human subject and withholding a treatment comprising an anti-HER3 antibody to the human subject whose HRG gene expression at an mRNA level is assessed as low.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.