Determination and correction of retention time and mass/charge shifts in LC-MS experiments
US11841352B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 31, 2019 |
| Grant date | Dec 12, 2023 |
| Priority date | — |
| Expiry date | Oct 4, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2030/862
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Methods are described for the automatic determination and correction of retention time shift of a MS data set relative to a control data set, to correct for retention time drifts endemic to targeted LCMS analyses. In an embodiment, a 2D grid of periodic MS spectra versus time is collected for a control experiment, and RT windows are determined with an additional set of unscheduled mass spectral analyses. During successive experiments, spectra from periodic MS scans are used to determine the correspondence between the current time and the time in the control experiment. The active set of MSn scans to be acquired by the instrument is then determined as the scans with adjusted retention time windows that bracket the corrected retention time.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.