Classification of nucleic acid templates

US11844666B2 · kind B2 · utility

Assignee

• PACIFIC BIOSCIENCES OF CALIFORNIA, INC. · US

Inventors

• Benjamin Flusberg · Atlanta, US
• Jonas Korlach · Camas, US
• Andrey Kislyuk · San Ramon, US
• Stephen Turner · Menlo Park, US
• Jon Sorenson · Alameda, US
• Kevin Travers · Menlo Park, US
• Cheryl Heiner · La Honda, US
• Austin B. Tomaney · Burlingame, US
• Patrick Marks · San Francisco, US
• Dale Webster · San Mateo, US
• Jeremiah Hanes · Woodside, US

Key dates

• Filing date: Mar 23, 2023
• Grant date: Dec 19, 2023
• Expiry date: Mar 23, 2043

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61F2250/0036
• WIPO field: Medical technology
• WIPO sector: Instruments

Abstract

Methods, compositions, and systems are provided for characterization of modified nucleic acids. In certain preferred embodiments, single molecule sequencing methods are provided for identification of modified nucleotides within nucleic acid sequences. Modifications detectable by the methods provided herein include chemically modified bases, enzymatically modified bases, abasic sites, non-natural bases, secondary structures, and agents bound to a template nucleic acid.