Sulfonylureas and related compounds and use of same

US11845715B2 · kind B2 · utility

Assignees

• The University Of Queensland · AU
• THE PROVOST, FELLOWS, FOUNDATION SCHOLARS, AND THE OTHER MEMBERS OF BOARD, OF THE COLLEGE OF THE HOLY AND UNDIVIDED TRINITY OF QUEEN ELIZABETH NEAR DUBLIN · IE

Inventors

• Luke O'Neill · Dublin, IE
• Rebecca Coll · Brisbane, AU
• Matthew Cooper · Cambridge, GB
• Avril Robertson · Norwood, AU
• Kate Schroder · Parramatta, AU

Key dates

• Filing date: Aug 18, 2021
• Grant date: Dec 19, 2023
• Expiry date: Aug 18, 2041

Classification

• Technology area (CPC —): General

Abstract

The present invention provides for certain sulfonyl ureas and related compounds which have advantageous properties and show useful activity in the inhibition of activation of the NLRP3 inflammasome. Such compounds are useful in the treatment of a wide range of disorders in which the inflammation process, or more specifically the NLRP3 inflammasome, have been implicated as being a key factor.