Patent · US Active

Ribonucleic acid purification

US11845772B2 · kind B2 · utility

1Cited by

61References

16Claims

0Family size

Assignee

ModernaTX, Inc. · US

Inventors

William Issa · Dedham, US
John Grant Aunins · Cambridge, US
Stephane Bancel · Cambridge, US

Key dates

Filing date	Jun 30, 2022
Grant date	Dec 19, 2023
Priority date	—
Expiry date	Jun 30, 2042

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12Q1/6806
WIPO fieldOrganic fine chemistry
WIPO sectorChemistry

Abstract

Disclosed herein are methods for purifying RNA comprising poly A. Also disclosed herein are compositions such as surfaces and oligonucleotides for purifying RNA comprising polyA. Other embodiments are also disclosed. Commercially-available resins having polythymidine oligonucleotide ligands typically contain less than 30 thymidine (2′deoxy) residues and some commercial resin suppliers utilize a distribution of dT chain lengths, not of a discreet length.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.