CRISPR/Cas screening platform to identify genetic modifiers of tau seeding or aggregation
US11845931B2 · kind B2 · utility
4Cited by
3References
37Claims
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Key dates
| Filing date | Mar 17, 2020 |
| Grant date | Dec 19, 2023 |
| Priority date | — |
| Expiry date | May 4, 2042 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01N2800/7047
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
Cas-protein-ready tau biosensor cells, CRISPR/Cas synergistic activation mediator (SAM)-ready tau biosensor cells, and methods of making and using such cells to screen for genetic modifiers of tau seeding or aggregation are provided. Reagents and methods for sensitizing such cells to tau seeding activity or tau aggregation or for causing tau aggregation are also provided.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.