Patent · US Active

Compositions and methods for delivery of nucleic acids to cells

US11850284B2 · kind B2 · utility

0Cited by
42References
22Claims
0Family size

Assignee

Inventors

Key dates

Filing dateAug 30, 2022
Grant dateDec 26, 2023
Priority date—
Expiry dateAug 30, 2042

Classification

  • Technology area (CPC C)Chemistry; Metallurgy
  • CPC primaryC12N2320/32
  • WIPO fieldPharmaceuticals
  • WIPO sectorChemistry

Abstract

Compositions and methods of use thereof for delivering nucleic acid cargo into cells are provided. The compositions typically include (a) a 3E10 monoclonal antibody or an antigen binding, cell-penetrating fragment thereof; a monovalent, divalent, or multivalent single chain variable fragment (scFv); or a diabody; or humanized form or variant thereof, and (b) a nucleic acid cargo including, for example, a nucleic acid encoding a polypeptide, a functional nucleic acid, a nucleic acid encoding a functional nucleic acid, or a combination thereof. Elements (a) and (b) are typically non-covalently linked to form a complex.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.