Nanofluidic flow cell and method of loading same
US11850595B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Dec 4, 2020 |
| Grant date | Dec 26, 2023 |
| Priority date | — |
| Expiry date | Feb 7, 2042 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01L2400/0481
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
A flow cell for confining molecules in a fluid. The flow cell includes an upper substrate, an upper support member, a center substrate, a membrane, a lower support member and a lower substrate. The lower support member comprises an imaging chamber it is positioned below the membrane and above the lower substrate. In one embodiment the membrane comprises a nanopore and nanoscale groove extending through the membrane. In another embodiment the lower substrate comprises an upper face in communication with the imaging chamber, and the upper face comprises a plurality of nanoscale grooves extending partially through the lower substrate. In both embodiments the upper substrate, upper support member, center substrate and membrane are displaceable through the imaging chamber, thereby causing molecules in the imaging chamber to be confined or trapped through the nanoscale groove(s) of the membrane or of the lower substrate.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.