Method for preparing pyridine compound substituted with trifluoromethylthio, difluoromethylthio or trifluoromethyl in meta position
US11851408B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 14, 2023 |
| Grant date | Dec 26, 2023 |
| Priority date | — |
| Expiry date | Jul 14, 2043 |
Classification
- Technology area (CPC B)Performing Operations; Transporting
- CPC primaryB01J31/146
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
A method for preparing a pyridine compound substituted with trifluoromethylthio, difluoromethylthio or trifluoromethyl in the meta position is provided, which includes S1. in a glove box filled with nitrogen, adding a catalyst, a solvent, pinacolborane, and pyridine to a reaction flask, stirring the mixture, and performing a reaction at 40-100° C. for 2-12 hours to obtain dihydropyridine; S2. adding a trifluoromethylthio reagent, a difluoromethylthio reagent, or a trifluoromethyl reagent to the reaction flask, stirring the mixture, and performing a reaction at room temperature to 80° C. for 2-12 hours to obtain trifluoromethylthio-, difluoromethylthio- or trifluoromethyl-substituted dihydropyridine; and S3. placing the reaction flask in the air or adding 2,3-dichloro-5,6-dicyanobenzoquinone, stirring same, and performing a reaction at room temperature for 4-12 hours, followed by distillation under reduced pressure to remove the solvent and column chromatography separation to obtain the meta-substituted pyridine compound.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.