AMPK activators

US11851429B2 · kind B2 · utility

Assignee

• KALLYOPE, INC. · US

Inventors

• Iyassu Sebhat · Jersey City, US
• Shuwen He · Fanwood, US
• Ann E. Weber · Scotch Plains, US
• Nancy A. Thornberry · Westfield, US
• Lisa KRUG · New York, US
• Paul RICHARDS · New York, US
• Brett Lauring · New York, US

Key dates

• Filing date: Jan 26, 2022
• Grant date: Dec 26, 2023
• Expiry date: Jan 26, 2042

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P31/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This disclosure is directed, at least in part, to AMPK activators useful for the treatment of conditions or disorders associated with AMPK. In some embodiments, the condition or disorder is associated with the gut-brain axis. In some embodiments, condition or disorder is associated with systemic infection and inflammation from having a leaky gut barrier. In some embodiments, the AMPK activators are gut-restricted compounds. In some embodiments, the AMPK activators are agonists or partial agonists.