Patent · US Active

Soluble heterodimeric T cell receptor, and preparation method and use thereof

US11851469B2 · kind B2 · utility

0Cited by

2References

14Claims

0Family size

Assignee

XLIFESC, LTD. · CN

Inventors

Yi Li · Shanghai, CN
Hui Fan · Changchun, CN

Key dates

Filing date	Nov 4, 2015
Grant date	Dec 26, 2023
Priority date	—
Expiry date	Mar 28, 2039

Classification

Technology area (CPC C)Chemistry; Metallurgy
CPC primaryC12N15/70
WIPO fieldPharmaceuticals
WIPO sectorChemistry

Abstract

Provided is a high-stability T cell receptor (TCR). The TCR comprises (i) the whole or a part of TCRα chain except a transmembrane domain thereof, and (ii) the whole or a part of TCRβ chain except a transmembrane domain thereof, both the (i) and the (ii) comprising a functional variable domain and at least a part of a constant domain of a TCR chain. An artificial interchain disulfide bond links the constant domains of the TCRα and β chains, and a Tm value of the T cell receptor is greater than or equal to 45° C.

Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.