Heterodimerizing Ig domains

US11851489B2 · kind B2 · utility

Assignee

• UNIVERSITAT STUTTGART · DE

Inventors

• Fabian RICHTER · Kirchheim unter Teck, DE
• Oliver SEIFERT · Stuttgart, DE
• Roland Kontermann · Jeffery Road, DE

Key dates

• Filing date: Jun 1, 2018
• Grant date: Dec 26, 2023
• Expiry date: Feb 28, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2317/94
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present invention provides a protein complex comprising heterodimerizing regions HRI and HRII, each comprised of antiparallel β-strands and intervening regions wherein HRI and HRII are each interspersed fusion proteins of two human constant regions of an immunoglobulin or immunoglobulin-like proteins. The present invention also provides nucleic acid molecules comprising a sequence encoding said protein complexes and vectors comprising the nucleic acid. The present invention also provides the protein complex, the nucleic acid and the vector for use as a medicament. The present invention further provides a method of determining the amino acid sequence of HRI and/or of the amino acid sequence of HRII. The present invention also provides a method of producing amino acid chains of HRI and/or amino acid chains of HRII. The present invention further provides the protein complex for use in the N prophylaxis, treatment or diagnosis of a disorder or a disease.