Composition and methods for inducing myeloid suppressive cells and use thereof
US11851677B2 · kind B2 · utility
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Key dates
| Filing date | Jun 13, 2018 |
| Grant date | Dec 26, 2023 |
| Priority date | — |
| Expiry date | Apr 7, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2533/50
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Compositions and methods for manufacturing induced immune regulatory cells comprising induced myeloid suppressive cells including MDSCs (myeloid-derived suppressor cells), dendritic cells, macrophages, and subpopulations thereof are provided. Also provided are methods and compositions for further modifying and modulating the induced immune regulatory cells to achieve enhanced therapeutic potential in treating autoimmune disorders, hematological malignancies, solid tumors, viral infections, neurodegenerative disorders, inflammatory conditions, or GvHD.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.