Deepsimulator method and system for mimicking nanopore sequencing
US11851704B2 · kind B2 · utility
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Key dates
| Filing date | Jun 23, 2021 |
| Grant date | Dec 26, 2023 |
| Priority date | — |
| Expiry date | Dec 25, 2041 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG16B40/30
- WIPO fieldComputer technology
- WIPO sectorElectrical engineering
Abstract
A method for sequencing biopolymers. The method includes selecting with a sequence generator module an input nucleotide sequence having plural k-mers; simulating with a deep learning simulator, actual electrical current signals corresponding to the input nucleotide sequence; identifying reads that correspond to the actual electrical current signals; and displaying the reads. The deep learning simulator includes a context-dependent deep learning model that takes into consideration a position of a k-mer of the plural k-mers on the input nucleotide sequence when calculating a corresponding actual electrical current.
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