Method and apparatus for small molecule detection by nanopipette
US11852624B1 · kind B1 · utility
Assignee
Inventors
Key dates
| Filing date | Jan 31, 2023 |
| Grant date | Dec 26, 2023 |
| Priority date | — |
| Expiry date | Jan 31, 2043 |
Classification
- Technology area (CPC G)Physics
- CPC primaryG01Q60/44
- WIPO fieldMeasurement
- WIPO sectorInstruments
Abstract
A system, apparatus, device and/or method for electrical label-free detection of single molecule via a glass or quartz nanopipette biosensor, one type of solid state nanopore biosensor based on resistive pulse measurements, are provided. The method of the subject invention effectively slows down the motion of biomolecules and concentrates them at the nanopipette tip. By driving biomolecules to come out of the nanopipette barrel and move in the fibrin hydrogel, unprecedented sensitivity using the typical size nanopipettes can be achieved. Small molecules such as doxorubicin, ATP, GTP, and short peptides can be easily detected with very high event rate, which greatly reduces the fabrication and measurement difficulties and open opportunities for various new applications for nanopipette biosensors.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.