Ready to use injectable formulations of melphalan and processes for preparation thereof

US11857677B2 · kind B2 · utility

Assignee

• RK PHARMA INC. · US

Inventors

• Ravishanker Kovi · Sparta, US
• Jayaraman Kannappan · Mahesana, IN
• Thupalli Ajeykumar Reddy · Bengaluru, IN
• Vamshi Yekkanti · Chilpur, IN
• Raghu Rami Reddy Kasu · Jamkhed, IN

Key dates

• Filing date: Dec 17, 2020
• Grant date: Jan 2, 2024
• Expiry date: Dec 17, 2040

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61K47/32
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present application provides stable ready-to-use injectable formulations of melphalan, methods for preparing storage-stable, ready-to-use injectable formulations that include melphalan, which are easy to administer without need of any reconstitution step and has a desirable solubility, stability, and safety profile. In other embodiments, provided are storage-stable, ready-to-use, injectable liquid parenteral formulations that include melphalan and other pharmaceutically acceptable excipients.