Fused bicyclic RAF inhibitors and methods for use thereof

US11858930B2 · kind B2 · utility

Assignee

• Jazz Pharmaceuticals Ireland Limited · IE

Inventors

• Andrew James Belfield · Macclesfield, GB
• Clifford David Jones · Grafton, GB
• Jean-François Margathe · Macclesfield, GB
• Chiara Colletto · Macclesfield, GB

Key dates

• Filing date: Jul 28, 2021
• Grant date: Jan 2, 2024
• Expiry date: Jul 28, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07D519/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

The present disclosure generally relates to improved synthesis of fused bicyclic Raf inhibitors of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof. The disclosure also relates to method of using the compound of formula (I), (I-A), (I-B), (II), or (III), or a pharmaceutically acceptable salt, tautomer, or stereoisomer thereof, for treating diseases such as cancer, including colorectal cancer.