Synthesis of uniformly defined molecular weight mannosylated dextrans and derivatives thereof
US11859023B2 · kind B2 · utility
Assignee
Inventors
Key dates
| Filing date | Jul 8, 2021 |
| Grant date | Jan 2, 2024 |
| Priority date | — |
| Expiry date | Jul 8, 2041 |
Classification
- Technology area (CPC A)Human Necessities
- CPC primaryA61K51/065
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
Disclosed herein is method for conjugating a metal chelating agent to a functionalized dextran by reacting a chelator with an aminated dextran backbone, where the chelator comprises a one, and only one, derivatized carboxylic acid group to form a chelator-dextran complex. In certain aspects, the dextran-chelator complex is substantially free of intra- or intermolecular crosslinking. In certain aspects, the functionalized dextran is an amine dextran, an alkynyl dextran, or a thiol dextran. In exemplary implementations, the functionalized dextran is an amine dextran. In further embodiments, one and only one carboxylic acid group on the chelating agent is derivatized as a N-hydroxysuccinimide (NHS) ester.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.