Sulfated oligosaccharides having anti-inflammatory activity

US11865137B2 · kind B2 · utility

Assignees

• The University of North Carolina at Chapel Hill · US
• The Research Foundation for The State University of New York · US

Inventors

• Katelyn Arnold · Durham, US
• Ding Xu · East Amherst, US
• Yongmei Xu · Durham, US
• Rafal Pawlinski · Chapel Hill, US
• Jian Liu · Los Angeles, US

Key dates

• Filing date: Nov 5, 2018
• Grant date: Jan 9, 2024
• Expiry date: Mar 8, 2039

Classification

• Technology area (CPC A): Human Necessities
• CPC primary: A61P29/00
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Provided herein are small molecule compounds, including non-anticoagulant heparan sulfate oligosaccharide molecules, having anti-inflammatory properties and capable of interacting with high mobility group box 1 (HMGB1) proteins in a manner sufficient to affect an interaction between the HMGB1 protein and a receptor for advanced glycation end products (RAGE). Also provided herein are methods of treating Paracetamol (APAP) overdose in subjects.