Composition for improving, preventing or treating skin disease comprising induced pluripotency stem cell-derived mesenchymal stem cells pretreated with interferon gamma and exosomes derived therefrom
US11865141B2 · kind B2 · utility
Assignees
Inventors
Key dates
| Filing date | Jan 7, 2019 |
| Grant date | Jan 9, 2024 |
| Priority date | — |
| Expiry date | May 2, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC12N2506/45
- WIPO fieldPharmaceuticals
- WIPO sectorChemistry
Abstract
The present invention may provide a method for producing induced pluripotency stem cell-derived mesenchymal stem cells (IFNγ-iMSC) pretreated with interferon-gamma; induced pluripotency stem cell-derived mesenchymal stem cells pretreated with interferon-gamma prepared by the method; a pharmaceutical composition for preventing or treating skin diseases, and a cosmetic composition for preventing or improving skin diseases, comprising culture thereof or exosome (IFNγ-iMSC-exo) isolated therefrom as an active ingredient. When the composition of the present invention is used, it is possible to provide a composition for skin diseases and a stem cell therapeutic agent, which have an improved immunomodulating function over conventional mesenchymal stem cells.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.