Methods and materials for using butyrylcholinesterases to treat cancer

US11865163B2 · kind B2 · utility

Assignee

• Mayo Foundation for Medical Education and Research · US

Inventors

• William S. Brimijoin · Rochester, US
• Liewei Wang · Rochester, US
• Yang Gao · Hangzhou City, CN
• Ping Chen · Rochester, US
• Liyi Geng · Rochester, US
• Jia Yu · Rochester, US
• Judy C. Boughey · Rochester, US
• Matthew P. Goetz · Rochester, US

Key dates

• Filing date: Sep 15, 2017
• Grant date: Jan 9, 2024
• Expiry date: Apr 12, 2040

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C12Y301/01008
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

This document provides methods and materials for using butyrylcholinesterases (BChE) to treat cancer (e.g., triple negative breast cancer or prostate cancer). For example, methods and materials for using nucleic acid vectors (e.g., viral vectors) to express BChE polypeptides under conditions that reduce the number of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) and/or reduce the growth rate of cancer cells (e.g., triple negative breast cancer cells or prostate cancer cells) within a mammal (e.g., a human) are provided.