7,7′-dihalo-3,3,3′,3′-tetramethyl-1,1′-spirobiindane and preparation method thereof

US11866393B2 · kind B2 · utility

Assignee

• ZHEJIANG UNIVERSITY · CN

Inventors

• Xufeng Lin · Hangzhou City, CN
• Linxi Yao · Hangzhou City, CN
• Shirui Chang · Hangzhou City, CN
• Lei Wang · Shanghai, CN

Key dates

• Filing date: Mar 22, 2022
• Grant date: Jan 9, 2024
• Expiry date: Apr 9, 2042

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07C2603/94
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

Disclosed are 7,7′-dihalo-3,3,3′,3′-tetramethyl-1,1′-spirobiindane and a preparation method thereof. The 7,7′-dihalo-3,3,3′,3′-tetramethyl-1,1′-spirobiindane is a compound represented by formula I, or an enantiomer, a raceme or a diastereomer thereof. The compound of formula I could be prepared by using a racemic or optically active 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-6,6′-diol as a raw material through a series of reactions. The 7,7′-dihalo-3,3,3′,3′-tetramethyl-1,1′-spirobiindane is a key intermediate for preparing 3,3,3′,3′-tetramethyl-1,1′-spirobiindane-based phosphine ligand compounds represented by formula II or III.