Total synthesis of prostaglandin J natural products by stereoretentive metathesis
US11866398B2 · kind B2 · utility
0Cited by
0References
10Claims
0Family size
Assignee
Inventors
Key dates
| Filing date | May 14, 2019 |
| Grant date | Jan 9, 2024 |
| Priority date | — |
| Expiry date | Nov 20, 2040 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07F15/0046
- WIPO fieldOrganic fine chemistry
- WIPO sectorChemistry
Abstract
This invention relates generally to the synthesis of Δ12-Prostaglandin J product using stereoretentive ruthenium olefin metathesis catalysts supported by dithiolate ligands. Δ12-Prostaglandin J products were generated with excellent selectivity (>99% Z) and in moderate to high/good yields (47% to 80% yield; 58% to 80% yield).
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.