Process for making a PD-1/PD-L1 inhibitor and salts and crystalline forms thereof

US11866434B2 · kind B2 · utility

Assignee

• Incyte Corporation · US

Inventors

• Dengjin Wang · Levittown, US
• Daniel Carper · Wilmington, US
• Zhongjiang Jia · Kennett Square, US
• Bo Shen · Ward, US
• Joseph A. Sclafani · Malvern, US
• Robert Wilson · Saratoga, US
• Jiacheng Zhou · Shanghai, CN
• Osama Suleiman · Cambridge, GB
• Mark Wright · Cambridge, GB

Key dates

• Filing date: Nov 5, 2021
• Grant date: Jan 9, 2024
• Expiry date: Dec 13, 2041

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07B2200/13
• WIPO field: Organic fine chemistry
• WIPO sector: Chemistry

Abstract

This application relates to processes and intermediates for the preparation of the PD-1/PD-L1 inhibitor (R)-1-((7-cyano-2-(3′-((2-(difluoromethyl)-7-((3-hydroxypyrrolidin-1-yl)methyl)pyrido[3,2-d]pyrimidin-4-yl)amino)-2,2′-dimethyl-[1,1′-biphenyl]-3-yl)benzo[d]oxazol-5-yl)methyl)piperidine-4-carboxylic acid, and salts and crystalline forms thereof, where the PD-1/PD-L1 inhibitor and solid forms and salt forms thereof are useful in the treatment of various diseases including infectious diseases and cancer.