Tumor homing and cell penetrating peptide-immuno-oncology agent complexes and methods of use thereof

US11866466B2 · kind B2 · utility

Assignee

• Blaze Bioscience, Inc. · US

Inventors

• Natalie Winblade Nairn · Seattle, US
• Julia E. Novak · Bainbridge Island, US
• Kenneth H. Grabstein · Seattle, US
• Dennis M. Miller · Woodinville, US
• Greg Hermanson · Loves Park, US
• Scott R. Presnell · Tacoma, US
• Mark Stroud · Seattle, US

Key dates

• Filing date: Dec 18, 2018
• Grant date: Jan 9, 2024
• Expiry date: Dec 4, 2039

Classification

• Technology area (CPC C): Chemistry; Metallurgy
• CPC primary: C07K2319/43
• WIPO field: Pharmaceuticals
• WIPO sector: Chemistry

Abstract

Peptide-immuno-oncology agent complexes (“peptide-I/O complexes”) that can home, target, migrate to, are directed to, are retained by, accumulate in, penetrate, or bind to the tumor microenvironment, tumor tissues, or cells or compartments or cytosol of cells thereof, or any combination thereof, are disclosed. Additionally disclosed are peptide-I/O complexes that can cross the blood-brain barrier. Pharmaceutical compositions and uses for peptide-I/O complexes comprising such peptides are also disclosed. Such compositions can be formulated for targeted delivery of an immuno-oncology agent (“I/O”) to the tumor microenvironment. Targeted compositions of the disclosure can deliver peptide-I/O complexes to target regions, tissues, structures or cells targeted by the peptide.