Multispecific polypeptide constructs having constrained CD3 binding and methods of using the same
US11866507B2 · kind B2 · utility
5Cited by
24References
10Claims
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Key dates
| Filing date | Apr 11, 2018 |
| Grant date | Jan 9, 2024 |
| Priority date | — |
| Expiry date | Apr 24, 2038 |
Classification
- Technology area (CPC C)Chemistry; Metallurgy
- CPC primaryC07K2317/75
- WIPO fieldBiotechnology
- WIPO sectorChemistry
Abstract
The invention relates generally to multispecific polypeptides having constrained CD3 binding. In some embodiments, the multispecific polypeptides contain cleavable linkers that, when cleaved, results in dual effector functions. Also provided are methods of making and using these multispecific polypeptides in a variety of therapeutic, diagnostic and prophylactic indications.
Source: USPTO / EPO open patent data. Objective bibliographic and citation counts.